Voltage clamp analysis of acetylcholine receptor desensitization in isolated mollusc neurones.
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چکیده
منابع مشابه
Desensitization of Mouse Nicotinic Acetylcholine Receptor Channels
The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery were estimated from the durations and frequencies of clusters of single-channel currents. Diliganded-open AChR desensitize much faster than either unliganded- or diliganded-closed AChR, which indicates that the desensitization rate constant depends on the status of the activation gate rather than the occup...
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1. Acetylcholine produced end-plate current (e.p.c.) noise is shown to be the results of statistical fluctuations in the ionic conductance of voltage clamped end-plates of Rana pipiens.2. These e.p.c. fluctuations are characterized by their e.p.c. spectra which conform to a relation predicted from a simple model of end-plate channel gating behaviour.3. The rate constant of channel closing alpha...
متن کاملRegulation of nicotinic acetylcholine receptor desensitization by Ca2+.
The relationship between the concentration of intracellular Ca2+ ([Ca2+](i)) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using the whole cell patch-clamp techniques in combination with microfluorescent [Ca2+](i) measurements. Recovery from desensitization was assessed with a paired-pulse agonist applicatio...
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Guo X, Lester RA. Regulation of nicotinic acetylcholine receptor desensitization by Ca . J Neurophysiol 97: 93–101, 2007. First published October 18, 2006; doi:10.1152/jn.01047.2005. The relationship between the concentration of intracellular Ca ([Ca ]i) and recovery from desensitization of nicotinic acetylcholine receptors (nAChRs) in rat medial habenula (MHb) neurons was investigated using th...
متن کاملCurrent-voltage relations in the isolated giant axon of the cockroach under voltage-clamp conditions.
Our understanding of the ionic exchanges taking place at the nerve membrane during electrical activity has been greatly increased by the application of the voltageclamp technique. This experimental method consists of the application of a stepwise change in potential to a given area of membrane and the simultaneous measurement of the current flow produced by this given potential gradient. The vo...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1979
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1979.sp013058